In recent years, the development and popularization of information technology and digital technology have provided convenient service support for patients and medical personnel. However, there is a practical problem in the field of medical service that the level of information security management is not high. By analyzing the application status of information security protection technology in the hospital information Department office, this paper identifies the problems existing in the construction of hospital information security protection, and puts forward effective solutions from the technical level. Further, with the help of the introduction of SSO authentication mechanism and the cross-application of various encryption technologies, To provide new help for the construction of information security protection in the hospital information department office.